A Robust Mathematical Formulation for Studying Elastically Coupled Motor-Cargo Systems
نویسندگان
چکیده
منابع مشابه
A Robust Mathematical Formulation for Studying Elastically Coupled Motor-Cargo Systems
Molecular motors are small, and, as a result, motor operation is dominated by high viscous friction and large thermal fluctuations from the surrounding fluid environment. The small size has made it very difficult to study the physical mechanisms of molecular motors. It is already difficult enough to see the motor itself, let alone to control the motor directly by applying an external force. In ...
متن کاملTransport of organelles by elastically coupled motor proteins.
Motor-driven intracellular transport is a complex phenomenon where multiple motor proteins simultaneously attached on to a cargo engage in pulling activity, often leading to tug-of-war, displaying bidirectional motion. However, most mathematical and computational models ignore the details of the motor-cargo interaction. A few studies have focused on more realistic models of cargo transport by i...
متن کاملElastically coupled molecular motors
We study the influence of filament elasticity on the motion of collective molecular motors. It is found that for a backbone flexibility exceeding a characteristic value (motor stiffness divided through the mean displacement between attached motors), the ability of motors to produce force reduces as compared to rigidly coupled motors, while the maximum velocity remains unchanged. The forceveloci...
متن کاملSynchronization of elastically coupled processive molecular motors and regulation of cargo transport.
The collective work of motor proteins plays an important role in cellular transport processes. Since measuring intermotor coupling and hence a comparison to theoretical predictions is difficult, we introduce the synchronization as an alternative observable for motor cooperativity. This synchronization can be determined from the ratio of the mean times of motor resting and stepping. Results from...
متن کاملFlow-Induced Instability Smart Control of Elastically Coupled Double-Nanotube-Systems
Flow induced vibration and smart control of elastically coupled double-nanotube-systems (CDNTSs) are investigated based on Eringen’s nonlocal elasticity theory and Euler-Bernoulli beam model. The CDNTS is considered to be composed of Carbon Nanotube (CNT) and Boron-Nitride Nanotube (BNNT) which are attached by Pasternak media. The BNNT is subjected to an applied voltage in the axial direction w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Computational and Theoretical Nanoscience
سال: 2006
ISSN: 1546-1955
DOI: 10.1166/jctn.2006.3080